兔抗KCNN2多克隆抗體

Background:

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants.

Applications:

ELISA, WB, IHC

Name of antibody:

KCNN2

Immunogen:

Synthetic peptide of human KCNN2

Full name:

potassium calcium-activated channel subfamily N member 2

Synonyms:

SK2; hSK2; SKCA2; KCa2.2; SKCa 2

SwissProt:

Q9H2S1

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human colorectal cancer

IHC Recommend dilution:

50-300

WB Predicted band size:

64 kDa

WB Positive control:

Mouse liver tissue lysate

WB Recommended dilution:

1000-5000