兔抗LIN28B多克隆抗體

WB Positive control:

Hela and 293 cells

WB Recommended dilution:

500-1000

WB Predicted band size:

27 kDa

SwissProt:

Q6ZN17

Synonyms:

CSDD2

Full name:

lin-28 homolog B

Immunogen:

Synthetic peptide of human LIN28B

Name of antibody:

LIN28B

Applications:

WB

Background:

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.