小鼠抗STAT1單克隆抗體

Background:

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.

Applications:

WB, IP

Name of antibody:

STAT1

Immunogen:

Fusion protein of human STAT1

Full name:

signal transducer and activator of transcription 1

Synonyms:

CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91

SwissProt:

P42224

WB Predicted band size:

87 kDa

WB Positive control:

SW480, MCF7, A549, COS7 and Hela cell lysates

WB Recommended dilution:

1000-5000