小鼠抗STAT6單克隆抗體

Background:

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, WB

Name of antibody:

STAT6

Immunogen:

Fusion protein of human STAT6

Full name:

signal transducer and activator of transcription 6

Synonyms:

STAT6B; STAT6C; D12S1644; IL-4-STAT

SwissProt:

P42226

WB Predicted band size:

94 kDa

WB Positive control:

HeLa whole cell lysate

WB Recommended dilution:

1000-5000