兔抗CHRND多克隆抗體

Background:

The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in this gene are a cause of multiple pterygium syndrome lethal type (MUPSL), congenital myasthenic syndrome slow-channel type (SCCMS), and congenital myasthenic syndrome fast-channel type (FCCMS). Several transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

CHRND

Immunogen:

Synthetic peptide of human CHRND

Full name:

cholinergic receptor nicotinic delta subunit

Synonyms:

ACHRD; CMS2A; CMS3A; CMS3B; CMS3C; FCCMS; SCCMS

SwissProt:

Q07001

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human tonsil

IHC Recommend dilution:

25-50