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  • AANAT抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW15666
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存:90
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中文名稱:AANAT抗原(重組蛋白)

英文名稱: AANAT Antigen (Recombinant Protein)

別      名: DSPS; SNAT

儲(chǔ)      存: 冷凍(-20℃)

相關(guān)類別: 抗原

概  述:

Fusion protein corresponding to a region derived from 35-194 amino acids of human AANAT


技術(shù)規(guī)格:

Full name:

aralkylamine N-acetyltransferase

Synonyms:

DSPS; SNAT

Swissprot:

Q16613

Gene Accession:

BC069434

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.