中文名稱: EIF3H抗原(重組蛋白)
英文名稱: EIF3H Antigen (Recombinant Protein)
別 名: EIF3S3; eIF3-p40; eIF3-gamma
儲 存: 冷凍(-20℃)
相關類別: 抗原
概 述:
Fusion protein corresponding to C terminal 300 amino acids of human EIF3H |
Full name: |
eukaryotic translation initiation factor 3, subunit H |
Synonyms: |
EIF3S3; eIF3-p40; eIF3-gamma |
Swissprot: |
O15372 |
Gene Accession: |
BC000386 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
Eukaryotic translation initiation factor 3 subunit H is a protein that in humans is encoded by the EIF3H gene. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP: methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. |