兔抗DCTN1多克隆抗體

Background:

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Applications:

ELISA, WB, IHC

Name of antibody:

DCTN1

Immunogen:

Fusion protein of human DCTN1

Full name:

dynactin 1

Synonyms：

P135; DP-150; DAP-150

SwissProt:

Q14203

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human liver cancer and human gastric cancer

IHC Recommend dilution:

100-300

WB Predicted band size:

142 kDa

WB Positive control:

293T cells and human fetal brain tissue

WB Recommended dilution:

200-1000