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  • IL21R抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW17952
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存:90
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中文名稱(chēng)IL21R抗原(重組蛋白)

英文名稱(chēng) IL21R Antigen (Recombinant Protein)

儲(chǔ)      存: 冷凍(-20℃)

相關(guān)類(lèi)別 抗原

概述

Fusion protein corresponding to a region derived from 20-232 amino acids of human IL21R


技術(shù)規(guī)格

Full name:

interleukin 21 receptorp

Synonyms:

NILR; CD360

Swissprot:

Q9HBE5

Gene Accession:

BC004348

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.