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  • 兔抗Rasgrf1(Phospho-Ser916) 多克隆抗體

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW19777
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
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中文名稱: 兔抗Rasgrf1(Phospho-Ser916) 多克隆抗體

英文名稱: Anti-Rasgrf1(Phospho-Ser916) rabbit polyclonal antibody

別    名: GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1

相關(guān)類別: 一抗

儲(chǔ)    存: 冷凍(-20℃) 避光

宿    主: Rabbit

抗    原: Rasgrf1(Phospho-Ser916)

反應(yīng)種屬: Human Mouse

標(biāo) 記 物: Unconjugate

克隆類型: rabbit polyclonal

技術(shù)規(guī)格

Background:

Ras activity is regulated by GAP (GTPase activating proteins) and GEFs (guanine nucleotide exchange factors). Ras-GRF1 (also known as CDC25Mm) is neuronal RasGEF and is regulated by heterotrimeric G proteins and calcium influx . Binding to calmodulin and phosphorylation stimulate Ras-GRF1 activity. Multiple PKA phosphorylation sites on Ras-GRF have been identified. Phosphorylation on the two major sites, Ser54 and Ser822, inhibits Ras-GRF activity. Carbachol (a muscarinic agonist)-induced phosphorylation on Ser916 is essential but not sufficient for maximal Ras-GRF activity.

Applications:

IHC

Name of antibody:

Rasgrf1(Phospho-Ser916)

Immunogen:

Peptide sequence around phosphorylation site of Serine 916(N-E-G(p)-T P) derived from Human Ras-GRF1.

Full name:

Ras protein-specific guanine nucleotide-releasing factor 1

Synonyms:

GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1

SwissProt:

Q13972

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100