兔抗NUAK1多克隆抗體

Background:

NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.

Applications:

ELISA, IHC

Name of antibody:

NUAK1

Immunogen:

Synthetic peptide of human NUAK1

Full name:

NUAK family, SNF1-like kinase, 1

Synonyms：

ARK5

SwissProt:

O60285

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human lung cancer and Human liver cancer

IHC Recommend dilution:

100-300