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  • 兔抗PSAP多克隆抗體

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW22007
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存:80
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中文名稱: 兔抗PSAP多克隆抗體


英文名稱: Anti-PSAP rabbit polyclonal antibody


別       名: FLJ00245; GLBA; MGC110993; SAP1


相關(guān)類別: 一抗


儲(chǔ)       存: 冷凍(-20℃) 避光


宿      主: Rabbit


抗      原: PSAP


反應(yīng)種屬: Human, Mouse, Rat


標(biāo)  記  物: Unconjugate


克隆類型:  rabbit polyclonal


技術(shù)規(guī)格

Background:

The PSAP gene encodes prosaposin, a precursor of four small nonenzymatic glycoproteins termed 'sphingolipid activator proteins' (SAPs) that assist in the lysosomal hydrolysis of sphingolipids. After proteolytic processing of the presaposin protein, these 4 released polypeptides are functional activators. Saposin A is encoded by residues 60 to 143 of PSAP, saposin B by 195 to 275, saposin C by 311 to 390, and saposin D by 405 to 487. They are four 12-14 kDa heatstable glycoproteins. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. Saposins A-D are required for the hydrolysis of certain sphingolipids by specific lysosomal hydrolases. Defects in PSAP are the cause of Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. This PSAP antibody (10801-1-AP) is expected to recognize both saposin A and B.

Applications:

WB

Name of antibody:

PSAP

Immunogen:

Fusion protein of human PSAP

Full name:

prosaposin

Synonyms:

FLJ00245; GLBA; MGC110993; SAP1

SwissProt:

P07602

WB Predicted band size:

58 kDa

WB Positive control:

HEK-293 cells

WB Recommended dilution:

500-2000