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  • 兔抗PTEN多克隆抗體

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    • 品牌 : 通蔚生物
    • 目錄號 : TW22046
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
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中文名稱:  兔抗PTEN多克隆抗體


英文名稱:  Anti-PTEN rabbit polyclonal antibody


別       名:  phosphatase and tensin homolog; BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; PTENbeta


相關(guān)類別:  一抗


儲       存:  冷凍(-20℃)


宿       主:  Rabbit


抗      原:  PTEN


反應(yīng)種屬:  Human, Mouse

標(biāo)  記  物:  Unconjugate


克隆類型:  rabbit polyclonal


技術(shù)規(guī)格

Background:

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.

Applications:

ELISA, IHC

Name of antibody:

PTEN

Immunogen:

Synthetic peptide of human PTEN

Full name:

phosphatase and tensin homolog

Synonyms:

BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; PTENbeta

SwissProt:

P60484

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human tonsil and Human esophagus cancer

IHC Recommend dilution:

25-100