兔抗GSK3B(Phospho-Tyr216)多克隆抗體

Background:

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.

Applications:

WB, IHC, IF

Name of antibody:

GSK3B (Phospho-Tyr216)

Immunogen:

Synthetic peptide of human GSK3B (Phospho-Tyr216)

Full name:

glycogen synthase kinase 3 beta (Phospho-Tyr216)

SwissProt:

P49841

IHC positive control:

Human breast carcinoma

IHC Recommend dilution:

50-100

WB Predicted band size:

47 kDa

WB Positive control:

293 cells treated with PMA

WB Recommended dilution:

500-1000

IF Positive control:

Hela cells

IF Recommended dilution

100-200