兔抗MADD多克隆抗體

Background:

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.

Applications:

WB, IHC, IF

Name of antibody:

MADD

Immunogen:

Synthesized peptide derived from internal of human MADD.

Full name:

MAP-kinase activating death domain

Synonyms：

DENN; IG20; RAB3GEP

SwissProt:

Q8WXG6

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

183 kDa

WB Positive control:

COLO cells, Hela cells and Jurkat cells lysates

WB Recommended dilution:

500-3000

IF positive control:

A549 cells

IF Recommend dilution:

100-500