兔抗ARRB2多克隆抗體

Background:

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB

Name of antibody:

ARRB2

Immunogen:

Synthetic peptide of human ARRB2

Full name:

arrestin beta 2

Synonyms:

ARB2; ARR2; BARR2

SwissProt:

P32121

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

40 kDa

WB Positive control:

HEPG2 and Hela cell lysates

WB Recommended dilution:

200-1000