兔抗CAV1多克隆抗體

Background:

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

Applications:

ELISA, WB

Name of antibody:

CAV1

Immunogen:

Synthetic peptide of human CAV1

Full name:

caveolin 1, caveolae protein, 22kDa

Synonyms：

CGL3; PPH3; BSCL3; VIP21; MSTP085

SwissProt:

Q03135

ELISA Recommended dilution:

2000-5000

WB Predicted band size:

20 kDa

WB Positive control:

Human leiomyosarcoma tissue

WB Recommended dilution:

500-2000