兔抗CBX5(Ab-92)多克隆抗體

Background:

Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Applications:

WB, IHC

Name of antibody:

CBX5(Ab-92)

Immunogen:

Synthesized non-phosphopeptide derived from human HP1 alpha around the phosphorylation site of serine 92 (R-K-S(p)-N-F).

Full name:

chromobox homolog 5

Synonyms：

HP1; HP1A; HEL25

SwissProt:

P45973

IHC positive control:

Human braina tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

22 kDa

WB Positive control:

Jurkat cells treated with insulin (0.01U/ml, 15mins) lysate

WB Recommended dilution:

500-3000