兔抗CD22多克隆抗體

Background:

The B lymphocyte specific CD22 antigen, also designated B-lymphocyte cell adhesion molecule (BLCAM), sialic acid-binding Ig-like lectin 2 (Siglec-2) and Leu-14, is a type I integral membrane glycoprotein, structurally similar to other cell adhesion molecules (CAMs), which acts as a regulator of B cell signaling. CD22 is expressed as both a cytoplasmic and membrane protein during discrete stages of B cell lymphocyte differentiation. The cytoplasmic form of CD22, expressed early in B cell development, is a useful marker for acute lymphocytic leukemia. The membrane form of CD22 is expressed in mature B cells prior to their differentiation into plasma cells.

Applications:

ELISA, IHC

Name of antibody:

CD22

Immunogen:

Fusion protein of human CD22

Full name:

CD22 molecule

Synonyms:

SIGLEC2; SIGLEC-2

SwissProt:

P20273

IHC positive control:

Human gastric cancer and human thyroid cancer

IHC Recommend dilution:

50-200