小鼠抗GCH1單克隆抗體

Background:

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

Applications:

WB, IHC

Name of antibody:

GCH1

Immunogen:

Fusion protein of human GCH1

Full name:

GTP cyclohydrolase 1

Synonyms:

GCH; DYT5; DYT14; DYT5a; GTPCH1; HPABH4B; GTP-CH-1

SwissProt:

P30793

IHC positive control:

Human lymphoma tissue and Human prostate cancer

IHC Recommend dilution:

200-500

WB Predicted band size:

28 KD

WB Positive control:

Jurkat cell lysate

WB Recommended dilution:

500-2000