小鼠抗IDH2單克隆抗體

Background:

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, WB

Name of antibody:

IDH2

Immunogen:

Fusion protein of human IDH2

Full name:

isocitrate dehydrogenase (NADP(+)) 2, mitochondrial

Synonyms:

IDH; IDP; IDHM; IDPM; ICD-M; D2HGA2; mNADP-IDH

SwissProt:

P48735

WB Predicted band size:

51 kDa

WB Positive control:

HepG2 whole cell lysate

WB Recommended dilution:

500-2000