兔抗HDAC5多克隆抗體

Background:

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

HDAC5

Immunogen:

Synthetic peptide of human HDAC5

Full name:

histone deacetylase 5

Synonyms：

HD5; NY-CO-9

SwissProt:

Q9UQL6

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human gastric cancer and Human tonsil

IHC Recommend dilution:

25-100