小鼠抗PSMA7單克隆抗體

Background:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9.

Applications:

WB, IHC

Name of antibody:

PSMA7

Immunogen:

Fusion protein of human PSMA7

Full name:

proteasome subunit alpha 7

Synonyms:

C6; HSPC; RC6-1; XAPC7; HEL-S-276

SwissProt:

O14818

IHC positive control:

Human pancreas tissue and Human breast tissue; Human thyroid tissue

IHC Recommend dilution:

500-2000

WB Predicted band size:

28 KD

WB Positive control:

A549, MCF7, 293T, Hela, A431, Raji, HepG2, K562, COLO205 cell lysates

WB Recommended dilution:

500-2000