兔抗GHRL多克隆抗體

Background:

This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression.

Applications:

ELISA, IHC

Name of antibody:

GHRL

Immunogen:

Synthetic peptide corresponding to a region derived from 104-117 amino acids of human GHRL

Full name:

ghrelin and obestatin prepropeptide

Synonyms:

MTLRP

SwissProt:

Q9UBU3

ELISA Recommended dilution:

5000-10000

IHC Positive control:

Human prostate cancer;

IHC Recommended dilution:

10-50