PLEKHO1抗原（重組蛋白）

Full name:

pleckstrin homology domain containing, family O member 1

Synonyms:

OC120; CKIP-1; RP11-458I7.3

Swissprot:

Q53GL0

Gene Accession:

BC010149

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by thePLEKHO1 gene. Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival.