中文名稱: 兔抗PSEN1多克隆抗體
英文名稱: Anti-PSEN1 rabbit polyclonal antibody
別 名: presenilin 1 AD3; FAD; PS1; PS-1; S182
相關(guān)類別: 一抗
抗 原: PSEN1
儲 存: 冷凍(-20℃)
宿 主: Rabbit
反應種屬: Human, Mouse
標 記 物: Unconjugate
克隆類型: rabbit polyclonal
Background: |
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. |
Applications: |
ELISA, WB, IHC |
Name of antibody: |
PSEN1 |
Immunogen: |
Synthetic peptide of human PSEN1 |
Full name: |
presenilin 1 |
Synonyms: |
AD3; FAD; PS1; PS-1; S182 |
SwissProt: |
P49768 |
ELISA Recommended dilution: |
5000-10000 |
IHC positive control: |
Human liver cancer; |
IHC Recommend dilution: |
20-100 |
WB Predicted band size: |
53 kDa |
WB Positive control: |
Human kidney tissue,RAW264.7 cell,Mouse kidney tissue,Mouse liver tissue lysates |
WB Recommended dilution: |
200-1000 |