兔抗CD101多克隆抗體

Background:

Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4+ CD56+ leukemic tumor cells.

Applications:

ELISA, WB, IHC

Name of antibody:

CD101

Immunogen:

Synthetic peptide of human CD101

Full name:

CD101 molecule

Synonyms:

V7; IGSF2; EWI-101

SwissProt:

Q93033

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human lung cancer and human tonsil

IHC Recommend dilution:

25-100

WB Predicted band size:

115 kDa

WB Positive control:

Rat heart tissue lysate

WB Recommended dilution:

200-1000