兔抗CEP290多克隆抗體

Background:

This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer.

Applications:

ELISA, IHC

Name of antibody:

CEP290

Immunogen:

Fusion protein of human CEP290

Full name:

centrosomal protein 290

Synonyms:

CT87; MKS4; POC3; rd16; BBS14; JBTS5; LCA10; NPHP6; SLSN6; 3H11Ag

SwissProt:

O15078

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and Human gastric cancer

IHC Recommend dilution:

25-100