小鼠抗BAX單克隆抗體

Background:

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Applications:

WB

Name of antibody:

BAX

Immunogen:

Fusion protein of human BAX

Full name:

BCL2 associated X, apoptosis regulator

Synonyms:

BCL2L4

SwissProt:

Q07812

WB Predicted band size:

21 kDa

WB Positive control:

COS7, Raji, CEM and Hela cell lysates

WB Recommended dilution:

1000-5000