兔抗ITGAM多克隆抗

Background:

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

ITGAM

Immunogen:

Synthetic peptide of human ITGAM

Full name:

integrin subunit alpha M

Synonyms:

CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6

SwissProt:

P11215

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer

IHC Recommend dilution:

50-100