兔抗ATF4(Ab-219) 多克隆抗體

Background:

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production By similarity. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4.

Applications:

WB

Name of antibody:

ATF4(Ab-219)

Immunogen:

Synthesized peptide derived from C-terminal of human ATF4.

Full name:

activating transcription factor 4

Synonyms：

CREB2; TXREB; CREB-2; TAXREB67

SwissProt:

P18848

WB Predicted band size:

39 kDa

WB Positive control:

A549 cells and Jurkat cells lysates

WB Recommended dilution:

500-3000