兔抗CASP10多克隆抗體

Background:

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Applications:

ELISA, IHC

Name of antibody:

CASP10

Immunogen:

Synthetic peptide of human CASP10

Full name:

caspase 10

Synonyms:

MCH4; ALPS2; FLICE2

SwissProt:

Q92851

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer; Human ovarian cancer

IHC Recommend dilution:

20-100