兔抗CEACAM1多克隆抗體

Background:

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.

Applications:

ELISA, WB, IHC

Name of antibody:

CEACAM1

Immunogen:

Synthetic peptide of human CEACAM1

Full name:

carcinoembryonic antigen related cell adhesion molecule 1

Synonyms:

BGP; BGP1; BGPI

SwissProt:

P13688

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and Human breast cancer

IHC Recommend dilution:

10-50

WB Predicted band size:

58 kDa

WB Positive control:

A549 cell lysate

WB Recommended dilution:

500-2000