小鼠抗MTDH單克隆抗體

Background:

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

Applications:

WB, IHC

Name of antibody:

MTDH

Immunogen:

Fusion protein of human MTDH

Full name:

metadherin (MTDH)

Synonyms:

3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3

SwissProt:

Q86UE4

IHC positive control:

carcinoma of human thyroid tissue and adenocarcinoma of human ovary tissue; human lymph node tissue and carcinoma of human lung tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

64 kDa

WB Positive control:

A549 cell lysate

WB Recommended dilution:

500-2000