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  • 兔抗INAVA多克隆抗體

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW9589
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
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中文名稱(chēng): 兔抗INAVA多克隆抗體

英文名稱(chēng): Anti-INAVA rabbit polyclonal antibody

別    名: innate immunity activator; C1orf106

相關(guān)類(lèi)別: 一抗

儲(chǔ)    存: 冷凍(-20℃)

宿    主: Rabbit

抗    原: INAVA

反應(yīng)種屬: Human, Mouse

標(biāo) 記 物: Unconjugate

克隆類(lèi)型: rabbit polyclonal

技術(shù)規(guī)格

Background:

Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).

Applications:

ELISA, IHC

Name of antibody:

INAVA

Immunogen:

Fusion protein of human INAVA

Full name:

innate immunity activator

Synonyms:

C1orf106

SwissProt:

Q3KP66

IHC positive control:

Human liver cancer

IHC Recommend dilution:

50-300